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Pomalidomide-amino-PEG3-NH2 hydrochloride

CAS No. 2380273-75-4

Pomalidomide-amino-PEG3-NH2 hydrochloride( —— )

Catalog No. M35170 CAS No. 2380273-75-4

Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pomalidomide-amino-PEG3-NH2 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.
  • Description
    Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    E3 Ligase Ligand
  • Recptor
    Ligand for E3 Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2380273-75-4
  • Formula Weight
    498.91
  • Molecular Formula
    C21H27ClN4O8
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (200.44 mM; Ultrasonic )
  • SMILES
    Cl.O=C(NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)COCCOCCOCCN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.?
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