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Pomalidomide-amino-PEG3-NH2 hydrochloride
CAS No. 2380273-75-4
Pomalidomide-amino-PEG3-NH2 hydrochloride( —— )
Catalog No. M35170 CAS No. 2380273-75-4
Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 61 | Get Quote |
|
| 5MG | 86 | Get Quote |
|
| 10MG | 125 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePomalidomide-amino-PEG3-NH2 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.
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DescriptionPomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetE3 Ligase Ligand
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RecptorLigand for E3 Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number2380273-75-4
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Formula Weight498.91
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Molecular FormulaC21H27ClN4O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (200.44 mM; Ultrasonic )
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SMILESCl.O=C(NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)COCCOCCOCCN
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.?
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